Bespoke assays for projects outside the standard workflow.
When a project doesn't fit our core service categories, Custom Services is where we design the assay around your question.
Most of our work fits into one of our core service categories — oncology, rare genetic diseases, compound–target. When a project doesn't, Custom Services is where we design the assay around your question.
Where we add value
Arrayed per-variant studies
Full cell viability curves and dose-response data for individual variants — for focused mechanistic work, target validation, or hit-to-lead studies where library-scale screening isn't the right shape.
Tagging-based readouts
Using geneSlice's protein tagging capability to support your specific workflow.
Gene editing in difficult genomic contexts
Repetitive regions, highly homologous sequences, loci with high off-target liability.
Custom phenotypic endpoints
Readouts not covered by standard assays.
Combinations of edits
Multi-locus, multi-variant, or variant-plus-tag combinations in a single cell model.
Other questions
If you have a gene target and a biological question, we will help you design the right assay.
Bioinformatic support
Our bioinformatics team, with strong statistical knowledge and expertise in R and Python supported by a software developer, can drive your project forward.
From question to scoped assay.
Custom projects start with a consultation: the gene, the biological question, the readout you need. We assess feasibility, propose an assay architecture, and scope the project against the proposal. Project execution follows the standard geneSlice™ pipeline — cell model development, screening, data analysis, delivery — adapted to the bespoke design.
Most custom projects run on a similar 6–12-month rhythm; some are shorter. Scoped per project.
A few we have delivered
Large deletions & genetic reversion
We established cell models carrying kilobase-scale deletions that removed pathogenic variants from a target gene and tested how the deletions affected drug sensitivity and gene function.
Additional past projects will be added here as more examples are approved for publication.
Additional past projects will be added here as more examples are approved for publication.